Scientific Program
All day Arrival and hotel check-in
16:00 Registration and distribution of course material
18:00 Get-together
October 13, 2025
08:00 – 08:30 OPENING SESSION
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WELCOME ADDRESS AND INTRODUCTION TO THE COURSE
M. Bialer, ILAE-EUROPE-Past Chair and Organizing Committee, Israel
J.H. Cross, ILAE-President and Organizing Committee, UK
E. Trinka, ILAE-EUROPE-Past Chair and Organizing Committee, Austria
INTRODUCTION TO THE COURSE
T. Tomson, Organizing Committee, Sweden
STUDENT INTRODUCTIONS
Each student to present him/herself
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08:30 – 10:45 INTRODUCTORY LECTURES
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Chairpersons: M. Koepp, UK
T. Tomson, Sweden
08:30 DEFINITIONS AND CLASSIFICATION OF SEIZURES, EPILEPSIES AND STATUS EPILEPTICUS
J.H. Cross, UK, E. Trinka, Austria
09:15 Discussion
09:30 GENERAL GOALS OF TREATMENT
T. Tomson, Sweden
10:00 Discussion
10:15 Coffee Break
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10:45 - 15:45 Session I:
THE PHARMACOLOGY OF ANTISEIZURE MEDICATIONS (ASMs)
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Chairpersons: M. Bialer, Israel
E. Perucca, Australia
10:45 ASMs: MECHANISMS OF ACTION
H.S. White, USA
11:15 Discussion
11:30 EXPERIMENTAL MODELS FOR THE DISCOVERY AND TESTING OF NEW
DRUGS TO TREAT SEIZURES AND EPILEPSY
H.S. White, USA
12:00 Discussion
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11:00 – 16:00 Session I:
THE PHARMACOLOGY OF ANTISEIZURE MEDICATIONS (ASMs), (cont)
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12:15 BASIC PRINCIPLES OF PHARMACOKINETICS
M. Bialer, Israel
13:00 Discussion
13:15 PHARMACOKINETICS OF ANTISEIZURE MEDICATION
M. Bialer, Israel, C. Johannessen Landmark, Norway
14:00 Discussion
14:15 Lunch
15:15 PHARMACOKINETICS VARIABILITY OF ANTISEIZURE MEDICATION AND THE USE OF TDM
C. Johannessen Landmark, Norway
15:45 Discussion
16:00 Coffee Break
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16:30 – 18:00 Session II:
DRUG INTERACTIONS
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Chairpersons: C. Johannessen Landmark, Norway
M. Koepp, UK
16:30 CLINICAL CASES: DRUG INTERACTIONS AND TDM (2 groups)
Tutors: M. Bialer, Israel, E. Perucca, Italy, C. Johannessen Landmark, Norway,
T. Tomson, Sweden
18:00 End of Sessions
October 14, 2025
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08:00 - 12:45 Session III:
TREATMENT ISSUES
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Chairpersons: E. Trinka, Austria
H.S. White, USA
08:00 DRUG INTERACTIONS IN EPILEPSY
M. Bialer, Israel
08:45 Discussion
09:00 WHEN TO TREAT AND WITH WHAT DOSE?
T. Tomson, Sweden, N. Specchio, Italy
09:30 Discussion
09:45 CLINICAL CASES: WHEN TO START TREATMENT (2 GROUPS)
Tutors: T. Tomson, Sweden, N. Specchio, Italy
11:00 Coffee Break
11:30 SELECTION OF DRUGS FOR INITIAL TREATMENT OF CHILDREN
N. Specchio, Italy
12:00 Discussion
12:15 SELECTION OF DRUGS FOR INITIAL TREATMENT OF ADULTS
E. Trinka, Austria
12:45 Discussion
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13:00 - 14:00 POSTER PRESENTATIONS I
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14:00 Lunch
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14:45 - 18:45 Session III:
TREATMENT ISSUES
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14:45 ADVERSE EFFECTS OF ASMs AND THEIR ASSESSMENT
E. Trinka, Austria
15:15 Discussion
15:30 PREGNANCY AND BREASTFEEDING
T. Tomson, Sweden
16:15 Discussion
16:30 Coffee Break
17:00 CLINICAL CASES – ACUTE SYMPTOMATIC SEIZURES IN ADULTS AND CHILDERN
(2 Groups 1 Adult 1 Children)
Tutors: E. Trinka, Austria, H. Cross UK
18:00 Discussion
October 15, 2025
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08:00 - 12:30 Session IV:
ASSESSING EFFICACY AND SAFETY
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Chairpersons: M. Koepp, UK
S. Auvin, France
08:00 WHAT STRATEGY WHEN THE INITIAL DRUG FAILS
E. Perucca, Italy
08:30 Discussion
08:45 HOW TO DEVELOP A DRUG FROM PHASE 1 TO PHASE 4
N. Specchio, Italy, F. Vigevano, Italy
09:30 Discussion
09:45 CRITICAL INTERPRETATION OF DRUG TRIALS IN EPILEPSY
E. Perucca, Australia
10:45 Discussion
11:00 Coffee break
11:30 INNOVATIVE TRIAL DESIGNS FOR RARE EPILPSY SYNDROMES
S. Auvin, France
12:15 Discussion
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12:30 - 13:30 POSTER PRESENTATIONS II
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13:30 Lunch
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14:30 - 18:30 Session IV:
ASSESSING EFFICACY AND SAFETY (cont)
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14:30 PRECISION MEDICINE IN EPILEPSY
S. Auvin, France, N. Specchio, Italy
15:00 Discussion
15:15 COGNITIVE COMORBIDITIES IN SEVERE EPILEPSIES OF CHILDHOOD:
CAN WE INFLUENCE THE OUTCOME?
F. Vigevano, Italy
15:45 Discussion
16:00 THE MEDICAL TREATMENT OF CHRONIC EPILEPSY AND ITS CO-MORBIDITIES
M. Koepp, UK
16:45 Discussion
17:00 Coffee Break
17:20 CLINICAL CASES: DRUG INTERACTIONS AND CLINICAL PK (2 groups)
Tutors: M. Bialer, Israel, E. Perucca, Italy, C. Johannessen Landmark, Norway,
T. Tomson, Sweden
18:30 End of Sessions
October 16, 2025
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08:30 - 09:30 POSTER PRESENTATIONS III
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09:30 - 12:30 Session V:
OPTIMIZING MEDICAL MANAGEMENT & TREATMENT STRATEGIES (I)
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Chairpersons: M. Koepp, UK
H. Cross, UK
09:30 TREATMENT OF STATUS EPILEPTICUS AND ACUTE REPETITIVE SEIZURES
E. Trinka, Austria
10:15 Discussion
10:30 Coffee break
11:00 CLINICAL CASES – STATUS EPILEPTICUS IN ADULTS AND CHILDREN
(2 Groups 1 Adult 1 Children)
Tutors: E.Trinka, Austria, N.Specchio, Italy
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12:30 - 13:30 POSTER PRESENTATIONS IV
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13:30 Lunch
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14:30 - 17:45 Session V:
OPTIMIZING MEDICAL MANAGEMENT & TREATMENT STRATEGIES (I) (cont)
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14:30 CLINICAL CASES - DEES (2 Groups)
N. Speechio, Italy, S. Auvin, France, H. Cross, UK, H. Cross, UK
15:45 Coffee Break
16:15 TREATMENT OF EPILEPSIES IN THE ELDERLY
M. Neufeld, Israel
16:45 Discussion
17:00 TERMINATION OF DRUG THERAPY IN SEIZURE-FREE PATIENTS
M. Koepp, UK
17:30 Discussion
17:45 End of Day
October 17, 2025
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08:30 – 09:30 POSTER PRESENTATIONS V
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09:30 CEREMONY: COURSE DIPLOMAS PRESENTED TO PARTICIPANTS
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10:00 - 14:00 Session VI:
OPTIMIZING MEDICAL MANAGEMENT (II): SPECIAL SITUATIONS/SPECIAL GROUPS
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Chairpersons: M. Neufeld, Israel
F. Vigevano, Italy
10:00 THERAPIES OF AUTOIMMUNE ENCEPHALITIS-ASSOCIATED EPILEPSIES
E. Trinka, Austria
10:30 Discussion
10:45 EMERGING AND FUTURE THERAPIES
E. Perucca, Australia
11:15 Discussion
11:30 Coffee Break
12:00 JOURNAL CLUB TUTORIAL
J.H. Cross, UK M. Neufeld, Israel E. Perucca, Australia N. Specchio, Italy F. Vigevano, Italy
14:00 Lunch